Lung Perfusion with Angiotensins I and II

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Extraction and measurement of circulating angiotensins I and II.

We describe a method for simultaneous extraction of angiotensins I and II from human blood. Blood was diluted with 10 volumes of isotonic saline containing ammonium ethylenediaminetetraacetate, and the angiotensin peptides were extracted by cation-exchange chromatography. The dilution effectively inhibits in vitro production of angiotensin I, conversion of angiotensin I to angiotensin II, and d...

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The existence of angiotensin II (AII) immunoreactivity in juxtaglomerular (JG) cells of rat kidney, which has been demonstrated previously by immunohistochemical studies, can be explained either as the product of intracellular synthesis or by the internalization of receptor-bound AII originating in plasma. To resolve these two alternative mechanisms, attempts were made to identify AI in JG cell...

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ژورنال

عنوان ژورنال: Circulation Research

سال: 1971

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.28.5.559